The time to reach steady state is determined by the half-life (3-5 half-lives, see Article 3 'Half-life' Aust Prescr 1988 11:57-9). The maintenanceĭose rate to achieve a desired concentration can be calculated if the clearance is known.ĭesired concentration (C ss) = maintenance dose rate / CL Given as a continuous infusion, the drug accumulates to a steady state concentration (C ss) determined only by the dose rate and clearance (CL) (see Article 1 'Clearance' Aust Prescr 1988 11:12-3). 1 illustrates the plasma concentration time course of theophylline given intravenously. Intravenous infusion and intermittent intravenous bolus dosingĬontinuous intravenous infusions and intermittent intravenous boluses are common ways of administering drugs such as gentamicin, lignocaine and theophylline. Information from previous articles in this series can be used to design dose regimens.ġ.
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